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ea0011p315 | Diabetes, metabolism and cardiovascular | ECE2006

Depot specific activation of inflammatory signalling molecules JNK and NFκB in human abdominal subcutaneous and omental adipose tissue

da Silva NF , Fowler AE , Harte AL , Baker AR , Kusminski CM , Creely SJ , O’Hare P , Kumar S , McTernan PG

Central obesity is strongly associated with sub-clinical inflammation, insulin resistance (IR) and type 2 diabetes mellitus (T2DM), but the intracellular mechanisms involved in its pathogenesis remain unclear. Recent Murine studies have implicated C-jun N terminal kinase (JNK) as an important molecule linking insulin action and inflammation, therefore we investigated JNK in human abdominal adipose tissue (AT). JNK expression/activity was assessed in abdominal subcutaneous (Abd...

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Endocrine Abstracts

Depot specific activation of inflammatory signalling molecules JNK and NFκB in human abdominal subcutaneous and omental adipose tissue

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